Chemokine receptors and HIV

Fusing HIV and chemokine receptors.

The role of chemokines and chemokine receptors in mycosis fungoides

Background: Chemokines are a family of cytokines initially characterized by their capacity to induce chemotaxis, or directed leukocyte migrations. These receptors are activated by chemotactic cytokines called chemokines. Interactions between chemokines and chemokine receptors also are involved in tumorigenesis, migration and invasion of lymphoma cells.Methods: An English literature search...

Chemokine receptors and mechanisms of cell death in HIV neuropathogenesis.

Several chemokine receptors are used as coreceptors for HIV-1 entry in the central nervous system (CNS). CCR5 is the major coreceptor together with CD4 for HIV-1 infection of microglia, the major target cells for HIV-1 infection in the CNS. CXCR4 and CCR3 are also expressed on microglia and can mediate infection by certain HIV-1 isolates but at lower efficiency than CCR5. Additional chemokine c...

Chemokine Receptors and HIV-1: An Attractive Pair?

In addition, CD4 can induce conformational changes in the viral glycoproteins, as measured by antibody epi-Department of Microbiology School of Medicine tope changes and gp120 shedding from the virus (reviewed by Sattentau and Moore, 1993), but viral binding and these conformational changes are not sufficient for HIV-1 infection of cells. In nonhuman cells expressing Binding of virus particles ...

The role of chemokine receptors in HIV infection.

A major breakthrough in HIV research 3 years ago was the identification of the elusive second receptors that the virus needs in addition to the CD4 molecule to get into human cells. A flurry of landmark papers in late 1995 and 1996 showed that members of the chemokine receptor family could be used by diVerent HIV isolates for entry in to CD4+ cells (reviewed in Moore et al 1 and Horuk), and tha...